Illegal Immigrants bring in 3rd World Diseases; Savage Tried to Warn America 20 years Ago

Since 03-16-07

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Parasite is a growing concern for healthcare professionals

By Rong-Gong Lin II
Times Staff Writer

March 15, 2007

http://www.latimes.com/news/local/la-me-chagas15mar15,0,5645224.story?coll=la-default-underdog

A little-known but potentially deadly parasite from Latin America has become one of the latest threats to the blood and organ supplies in the United States, especially in Los Angeles, where many donors have traveled to affected countries, health officials say.

Last year, two heart transplant patients at different Los Angeles hospitals contracted the parasitic disease, called Chagas, causing health authorities to issue a national bulletin. Within months, both patients subsequently died, although not directly from Chagas, according to the U.S. Centers for Disease Control and Prevention.

The parasite, which is generally passed to humans from a blood-sucking insect that looks like a striped cockroach, can feed over years on tissues of the heart and gastrointestinal tract. After decades, tissues can be eroded so much that the organs fail.

Insect transmission of the parasite in the United States is rare, but public health and blood bank officials have been concerned about its increasing prevalence in the blood supply.

In 1996, using an experimental test, the American Red Cross found that one in 9,850 blood donors in the L.A. area tested positive for the parasite, Trypanosoma cruzi. Two years later, it was one in every 5,400. By 2006, a more refined test detected the parasite in one in 3,800 donors. About 10% to 30% of infected people develop symptoms of chronic disease, experts say.

By contrast, HIV, which blood banks screen for, shows up in one of every 30,000 donors, said Susan Stramer, executive scientific officer for the Red Cross.

If caught early, strong anti-protozoal drugs such as nifurtimox can bring the parasite to undetectable levels or, in some cases, eliminate it entirely.

If the parasite is given the chance to multiply over years or decades, however, those infected may have to be treated with heart-regulating drugs or get a pacemaker or heart transplant.

The U.S. Food and Drug Administration approved a test suitable for widespread screening in December. Blood banks have now begun systematically checking their supplies for the Chagas parasite.

By late January, the American Red Cross and Phoenix-based Blood Systems, which collect about 65% of the U.S. blood supply, had started screening blood for T. cruzi. Other banks, including the Blood Bank of San Bernardino and Riverside Counties, have no immediate plans for screening but are monitoring test results from banks that are using the test. In late February, the CDC reported that the "FDA is expected to recommend implementation of the test by all blood-collection establishments."

No organ donors in the United States are now being screened for the parasite, although the organ procurement agency that covers much of Southern California plans to begin testing some donors in mid-April. At first, the screening will be focused on people who have lived in or traveled to rural parts of Latin America, said Thomas Mone, chief executive of the agency, OneLegacy.

In Latin America, about 10 million to 12 million people are believed to be infected with the Chagas parasite. As many as 1 million of them are expected to die from the disease unless there are advances in treatment, according to Dr. James Maguire, a University of Maryland expert on the disease.

"Chagas is very, very prevalent in South and Central America," said Marek Nowicki, a USC blood-disease expert who studied the effect of Chagas on the Southern California organ supply with the National Institute of Transplantation.

"The number of [immigrant] Latinos in Southern California, Texas and other parts of the United States are growing, but especially in L.A., a large proportion of organ donors are Latino," Nowicki said. "They're basically bringing with them the disease prevalence in the area they used to live."

The problem is not limited to immigrants. Tourists, too, can be carriers. The heart transplant cases in Los Angeles last year illustrate the problem.

One donor was a native of El Salvador living in Los Angeles, and the other was born in the U.S. but had traveled to Guadalajara, Mexico, where T. cruzi is endemic.

Richard Edward Russo, then 73, received the heart from the Salvadoran native. The Burbank retiree appeared to be recovering nicely last year when, several weeks after his transplant at St. Vincent Medical Center in Los Angeles, he developed a fever and a rash. He complained of being tired and couldn't eat or walk.

About the same time, a 64-year-old man developed similar symptoms after receiving a transplant at UCLA Medical Center. He had received the heart from the American tourist.

At both hospitals, doctors submitted the patients to a battery of tests, concluding separately that they had Chagas.

The CDC sent anti-parasitic medication out from Atlanta. The drug reduced the parasite in the blood of both men to undetectable levels. But Russo never got better, his wife, Carolyn, said. He suffered from other hospital-acquired infections and had pneumonia at least twice.

"It just went downhill," she said. Russo died in June 2006.

As a result of the cases, the CDC last summer warned doctors that the prevalence of infection might be higher than previously thought, especially in areas like Los Angeles County.

Chagas is a clear reminder that "diseases don't have geographic borders anymore," said Dr. Suman Radhakrishna, an infectious diseases expert in Los Angeles who helped treat Russo. Doctors need to be "cognizant that diseases happening elsewhere in the world can happen in our backyard too."

Another disease, cysticercosis, caused by tapeworm larvae, is believed to cause as many as 10% of the seizures reported to large urban emergency rooms in California and New Mexico. Dr. Ashok Jain, a USC emergency room doctor, said the figure may be as high as 20% at Los Angeles County USC Medical Center.

It is spread through ingestion, not the blood or organ supply.

"When I was in Cook County in Chicago, I didn't even know it existed," said Jain, an associate professor of clinical emergency medicine at USC. "Then I came to L.A. County … and oh, God, there were so many cases."

Diseases like Chagas and cysticercosis have emerged as an issue for some opponents of illegal immigration, who argue that exotic diseases are often spread by illegal immigrants.

"Curbing illegal entry will diminish the problem of exposure to such diseases because legal immigrants are medically screened to protect the U.S. public," said Jack Martin, special projects director for the Federation for American Immigration Reform, an immigration control group..

Public health officials say the migration of diseases has always been an issue — and is especially so today, in an increasingly mobile world with a global economy. Many urge caution, not alarm.

"I don't want people to overreact, but I don't want people to ignore it," said Victor Tsang, chief of the immunochemistry lab at the CDC's Division of Parasitic Diseases. "The more we pay attention to it, the better off we are."

ron.lin@latimes.com